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After doing so, the area must then be washed with hot water and treated with antiseptic liquid. Once all these preparatory steps are done, Dermatend may then be applied to the offending blemish. For effective mole or skin tag removal, leave it on for forty to sixty minutes. A scab will develop on the mole or skin tag in the next day, which will then fall off after a few more days. After the protrusion falls off, the healing process then begins. Once the skin is completely healed, then mole or skin tag removal process is a success.